Cellular and Molecular Biomechanics Laboratory

The laboratory of Dr. Cheng Zhu at Georgia Tech

Recent Publications

Type Date Title Link
2/14/2020 From cellular to molecular mechanobiology. Full
2/5/2020 Mechanotransduction in T Cell Development, Differentiation and Function. Full
1/21/2020 Calibration for computer experiments with binary responses and application to cell adhesion study Full
1/21/2020 Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex. Full
11/1/2019 Single-molecule investigations of T-cell activation. Full

Positions

Please email Dr. Cheng Zhu for more information

People

Principal Investigator

Dr. Cheng Zhu

cheng.zhu@bme.gatech.edu

Research Scientists

Dr. Kaitao Li

KaitaoLi@gatech.edu

Post-doctorates

Dr. Zhou Yuan

zyuan8@gatech.edu

Dr. Fangyuan Zhou

fzhou22@gatech.edu

Graduate Students

Makala Faniel

makalaf@gatech.edu

Fletcher Griffitts

griffitts@gatech.edu

David Reyes Aguilar

daguilar31@gatech.edu

Aaron Rosado

arosado@gatech.edu

Valencia Watson

vwatson7@gatech.edu

Undergraduate Students

Laboratory Alumni

Jeffrey Butler

jbutler80@gatech.edu

Dr. Paul Cardenas-Lizana

pacl3@gatech.edu

Dr. Yunfeng Chen

chen.yunfeng@hotmail.com

Dr. Chenghao Ge

cge8@gatech.edu

Dr. Jingsung Hong

hjs0811@gmail.com

Dr. Prithi Jothikumar

pjothikuma3@gatech.edu

Dr. Hyun-Jung Lee

hjlee@gatech.edu

Dr. Jiexi Liao

jliao8@gatech.edu

Dr. Billy Rittase

william.rittase@gmail.com

Samuel Ruipérez Campillo

sruiperez3@gatech.edu

Dr. Muaz Rushdi

nmnr3@gatech.edu

Dr. Ning Wu

angelia_wu@126.com

Laboratory Staff

Research

Welcome!

Welcome to the Zhu lab. We study single molecular adhesion with force spectroscopy for various cells and disease models. We pioneered in the discovery of force-prolonged bond lifetime, or the "catch bond," using the biomembrane force probe paired with mutation studies and molecular dynamics simulations.

T Cell Development, Antigen Recognition, and Activation

T cells are an important subset of the immune system that plays a pivotal role in regulating various diseases. T cells functions are influenced both by biochemical and biophysical properties at local microenvironment that influences receptor-ligand interactions. Our goal is to understand how these interactions mediated by mechanical properties translate into intracellular signaling, thereby affecting cellular function and fate.

Platelet Mechanobiology

Platelets are key players in both hemostasis and thrombosis. Mechanical stimuli are important in the circulation system. We strive to understand platelet activation, mechanotransduction, and hyperreactivity by characterizing surface receptor-ligand binding kinetics and intracellular signaling using tools such as the biomembrane force probe, biosensors, and mutation studies.

Instruments

Biomembrane Force Probe

BFP

Measures single ligand-receptor interactions under force

Micropipette adhesion frequency assay

Measures adhesion frequency of single receptor-ligand interactions

Atomic force microscope

AFM

Home-made AFM that measures protein-protein binding kinetics

Horizontal atomic force microscope

HAFM

AFM on which the cantilever works horizontally (parallel to the earth); can measure receptor-ligand binding kinetics under force on live cells

Micropipette forge

Home-made micropipette factory: makes pipettes of various sizes

Publications

Title First Author Journal Date PMID DOI More Information
From cellular to molecular mechanobiology. Cheng Zhu APL bioengineering 2/14/2020 31965350 10.1063/1.5129937 More Info
Mechanotransduction in T Cell Development, Differentiation and Function. Muaz Rushdi, Kaitao Li Cells 2/5/2020 26051539 10.3390/cells9020364 More Info
Calibration for computer experiments with binary responses and application to cell adhesion study Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, CF Wu Journal of the American Statistical Association 1/21/2020 None 10.1080/01621459.2019.1699419 More Info
Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex. Zhenhai Li, Hyunjung Lee, Suzanne G. Eskin, Shoichiro Ono, Cheng Zhu, Larry V. McIntire Biomechanics and modeling in mechanobiology 1/21/2020 12525176 10.1007/s10237-019-01284-5 More Info
Single-molecule investigations of T-cell activation. Li Kaitao, William Rittase Current opinion in biomedical engineering 11/1/2019 27192323 10.1016/j.cobme.2019.10.005 More Info
Dynamic bonds and their roles in mechanosensing. Cheng Zhu Current opinion in chemical biology 9/27/2019 27065098 10.1016/j.cbpa.2019.08.005 More Info
Mechanosensing through immunoreceptors. Cheng Zhu Nature immunology 9/18/2019 31534240 10.1038/s41590-019-0491-1 More Info
Domain-specific mechanical modulation of VWF-ADAMTS13 interaction. Zhenhai Li Molecular biology of the cell 7/19/2019 31067148 10.1091/mbc.E19-01-0021 More Info
A Generalized Gaussian Process Model for Computer Experiments With Binary Time Series Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, C. F. Jeff Wu Journal of the American Statistical Association 5/28/2019 None 10.1080/01621459.2019.1604361 More Info
Abstract 3236: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade Duane Moogk, Lin Wang, Kaitao Li, Zhou Yuan, Jeffrey Weber, Iman Osman, Cheng Zhu and Michelle Krogsgaard AACR; Cancer Res 3/29/2019 None 10.1158/1538-7445.AM2019-3236 More Info

Contact Zhu Lab

If you would like to contact the laboratory of Dr. Cheng Zhu, please get in touch with Larissa (E-mail)

For information about web design or web application design used in this website please contact Aaron (E-mail)

The website is administrated by Jiexi Liao (E-mail)