Cellular and Molecular Biomechanics Laboratory

The laboratory of Dr. Cheng Zhu at Georgia Tech

Recent Publications

Type Date Title Link
9/18/2019 Mechanosensing through immunoreceptors. Full
5/28/2019 A Generalized Gaussian Process Model for Computer Experiments With Binary Time Series Full
5/8/2019 Domain-specific mechanical modulation of VWF-ADAMTS13 interaction. Full
3/29/2019 Abstract 3236: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade Full
3/25/2019 An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation. Full

Positions

Please email Dr. Cheng Zhu for more information

People

Principal Investigator

Dr. Cheng Zhu

cheng.zhu@bme.gatech.edu

Research Scientists

Dr. Kaitao Li

KaitaoLi@gatech.edu

Post-doctorates

Dr. Fangyuan Zhou

fzhou22@gatech.edu

Graduate Students

Undergraduate Students

Jeffrey Butler

jbutler80@gatech.edu

Woo Jin Shim

wshim9@gatech.edu

Laboratory Alumni

Dr. Paul Cardenas-Lizana

pacl3@gatech.edu

Dr. Yunfeng Chen

chen.yunfeng@hotmail.com

Dr. Chenghao Ge

cge8@gatech.edu

Dr. Jingsung Hong

hjs0811@gmail.com

Dr. Prithi Jothikumar

pjothikuma3@gatech.edu

Dr. Hyun-Jung Lee

hjlee@gatech.edu

Dr. Billy Rittase

william.rittase@gmail.com

Samuel Ruipérez Campillo

sruiperez3@gatech.edu

Dr. Ning Wu

angelia_wu@126.com

Laboratory Staff

Research

Welcome!

Welcome to the Zhu lab. We study single molecular adhesion with force spectroscopy for various cells and disease models. We pioneered in the discovery of force-prolonged bond lifetime, or the "catch bond," using the biomembrane force probe paired with mutation studies and molecular dynamics simulations.

T Cell Development, Antigen Recognition, and Activation

T cells are an important subset of the immune system that plays a pivotal role in regulating various diseases. T cells functions are influenced both by biochemical and biophysical properties at local microenvironment that influences receptor-ligand interactions. Our goal is to understand how these interactions mediated by mechanical properties translate into intracellular signaling, thereby affecting cellular function and fate.

Platelet Mechanobiology

Platelets are key players in both hemostasis and thrombosis. Mechanical stimuli are important in the circulation system. We strive to understand platelet activation, mechanotransduction, and hyperreactivity by characterizing surface receptor-ligand binding kinetics and intracellular signaling using tools such as the biomembrane force probe, biosensors, and mutation studies.

Instruments

Biomembrane Force Probe

BFP

Measures single ligand-receptor interactions under force

Micropipette adhesion frequency assay

Measures adhesion frequency of single receptor-ligand interactions

Atomic force microscope

AFM

Home-made AFM that measures protein-protein binding kinetics

Horizontal atomic force microscope

HAFM

AFM on which the cantilever works horizontally (parallel to the earth); can measure receptor-ligand binding kinetics under force on live cells

Micropipette forge

Home-made micropipette factory: makes pipettes of various sizes

Publications

Title First Author Journal Date PMID DOI More Information
Mechanosensing through immunoreceptors. Cheng Zhu Nature immunology 9/18/2019 31534240 10.1038/s41590-019-0491-1 More Info
A Generalized Gaussian Process Model for Computer Experiments With Binary Time Series Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, C. F. Jeff Wu Journal of the American Statistical Association 5/28/2019 None 10.1080/01621459.2019.1604361 More Info
Domain-specific mechanical modulation of VWF-ADAMTS13 interaction. Zhenhai Li Molecular biology of the cell 5/8/2019 31067148 10.1091/mbc.E19-01-0021 More Info
Abstract 3236: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade Duane Moogk, Lin Wang, Kaitao Li, Zhou Yuan, Jeffrey Weber, Iman Osman, Cheng Zhu and Michelle Krogsgaard AACR; Cancer Res 3/29/2019 None 10.1158/1538-7445.AM2019-3236 More Info
An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation. Yunfeng Chen Nature materials 3/25/2019 30911119 10.1038/s41563-019-0323-6 More Info
Calibration for computer experiments with binary responses and application to cell adhesion study Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, CF Wu Arxiv 3/20/2019 None More Info
Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level. Hyunjung Lee Journal of cell science 2/4/2019 30659118 10.1242/jcs.216911 More Info
Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Peng Wu Molecular cell 1/30/2019 30711376 10.1016/j.molcel.2018.12.018 More Info
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Gurpanna Saggu Nature communications 11/29/2018 23310953 10.1038/s41467-018-07506-1 More Info
A TCR mechanotransduction signaling loop induces negative selection in the thymus. Jinsung Hong Nature immunology 11/12/2018 30420628 10.1038/s41590-018-0259-z More Info

Contact Zhu Lab

If you would like to contact the laboratory of Dr. Cheng Zhu, please get in touch with Larissa (E-mail)

For information about web design or web application design used in this website please contact Aaron (E-mail)

The website is administrated by Jiexi Liao (E-mail)