Welcome to the Zhu lab. We study single molecular adhesion with force spectroscopy for various cells and disease models. We pioneered in the discovery of force-prolonged bond lifetime, or the "catch bond," using the biomembrane force probe paired with mutation studies and molecular dynamics simulations.
T cells are an important subset of the immune system that plays a pivotal role in regulating various diseases. T cells functions are influenced both by biochemical and biophysical properties at local microenvironment that influences receptor-ligand interactions. Our goal is to understand how these interactions mediated by mechanical properties translate into intracellular signaling, thereby affecting cellular function and fate.
Platelets are key players in both hemostasis and thrombosis. Mechanical stimuli are important in the circulation system. We strive to understand platelet activation, mechanotransduction, and hyperreactivity by characterizing surface receptor-ligand binding kinetics and intracellular signaling using tools such as the biomembrane force probe, biosensors, and mutation studies.
|Title||First Author||Journal||Date||PMID||DOI||More Information|
|Mechanosensing through immunoreceptors.||Cheng Zhu||Nature immunology||9/18/2019||31534240||10.1038/s41590-019-0491-1||More Info|
|A Generalized Gaussian Process Model for Computer Experiments With Binary Time Series||Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, C. F. Jeff Wu||Journal of the American Statistical Association||5/28/2019||None||10.1080/01621459.2019.1604361||More Info|
|Domain-specific mechanical modulation of VWF-ADAMTS13 interaction.||Zhenhai Li||Molecular biology of the cell||5/8/2019||31067148||10.1091/mbc.E19-01-0021||More Info|
|Abstract 3236: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade||Duane Moogk, Lin Wang, Kaitao Li, Zhou Yuan, Jeffrey Weber, Iman Osman, Cheng Zhu and Michelle Krogsgaard||AACR; Cancer Res||3/29/2019||None||10.1158/1538-7445.AM2019-3236||More Info|
|An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation.||Yunfeng Chen||Nature materials||3/25/2019||30911119||10.1038/s41563-019-0323-6||More Info|
|Calibration for computer experiments with binary responses and application to cell adhesion study||Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, CF Wu||Arxiv||3/20/2019||None||More Info|
|Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level.||Hyunjung Lee||Journal of cell science||2/4/2019||30659118||10.1242/jcs.216911||More Info|
|Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition.||Peng Wu||Molecular cell||1/30/2019||30711376||10.1016/j.molcel.2018.12.018||More Info|
|Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment.||Gurpanna Saggu||Nature communications||11/29/2018||23310953||10.1038/s41467-018-07506-1||More Info|
|A TCR mechanotransduction signaling loop induces negative selection in the thymus.||Jinsung Hong||Nature immunology||11/12/2018||30420628||10.1038/s41590-018-0259-z||More Info|