B.S. Bioengineering (Biotechnology) 2011, University of California, San Diego
T cell triggering plays a critical role in the initiation of the adaptive immune response in our body. However, the exact mechanism of T cell activation is still unclear to date. I am interested in unraveling the 'black box' surrounding T cell triggering and understanding how exact does ligand recognition lead to T cell triggering. I focus primarily on investigating the interaction between TCR and its surrounding CD3 subunits using a range of methodologies including the micropipette assay, BFP, and DNA-based tension sensors.
Zhang Y., Ge G., Zhu C.,, and Salaita K., 2014, " DNA-based digital tension probes reveal integrin forces during early cell adhesion. ", Nat Commun. DOI: doi:10.1038/ncomms6167