Dr. Jiexi Liao

Platelets are key players in both hemostasis and thrombosis. Mechanical stimuli are important in the hemodynamic environment of the circulation system. I want to understand platelet activation, mechanotransduction, and hyperreactivity by characterizing receptor-ligand binding kinetics and intracellular signaling using tools such as the biomembrane force probe, biosensors, and mutation studies. The platelet surface molecules that I am interested in are integrin alpha-2b-beta-3 and GPIb-alpha. The practical end goal is to improve medical diagnosis and treatment for diseases such as atherothrombosis and diabetes, where mechanical cues could play a major role.

J. Liao and J. Gulley, "Time-frequency control of ultrafast plasma generation in dielectrics," Journal of the Optical Society of America B. 31 (2014) 2973-2980. DOI: 10.1364/JOSAB.31.002973

N. M. Aimon, J. Liao, C. A. Ross. Simulation of inhomogeneous magnetoelastic anisotropy in ferroelectric/ferromagnetic nanocomposites, Applied Physics Letters. 101 (2012) 232901(1)-232901(5). DOI: 10.1063/1.4768958