Kaitao Li

KaitaoLi@gatech.edu

Position: Post-doctorate

Education

M.S. Biomedical Engineering 2009, Peking University, China B.S. Mechanical Engineering 2006, Peking University, China

Research

2D interactions of PD-1 and PD-Ls and their interplay with TCR signaling

Program death 1 (PD-1) represents a promising therapeutic target, as blockade of the interactions of PD-1 with its two ligands, PD-L1 and PD-L2, has been shown to restore responses of exhausted antigen-specific T cells in a variety of chronic infectious diseases and cancer. Mechanistically, it has been shown that PD-1, upon ligand binding, co-localizes with T-cell receptor (TCR) microclusters engaged with peptide-major histocompatibility complex (pMHC) and recruits Src homology region 2 domain-containing phosphatase 2 (SHP-2) to attenuate TCR-triggered signaling. However, there still lacks a precise definition of how (and at what level) PD-1 suppresses TCR antigen recognition and how the two streams of signals crosstalk to yield potent inhibition. My research focuses on understanding the interaction of PD-1 and PD-Ls in the native cellular environment, as well as how such interaction interplay with T-cell antigen recognition/activation at the level of cell surface molecular interaction and the level of intracellular signal transduction.

Publications

Zhang, W., Li, K., Zhu, X., Wu, D., Shang, W., Yuan, X., Huang, Z., Zheng, M., Wang, X., Yang, D., Liu, J., Cheng, H. 2014. Subsarcolemmal mitochondrial flashes induced by hypochlorite stimulation in cardiac myocytes. Free Radic Res 48(9):1085-1094

Li, K., Zhang, W., Fang, H., Xie, W., Liu, J., Zheng, M., Wang, X., Wang, W., Tan, W., Cheng, H. 2012. Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes. Biophysical Journal 102(5): 1011-1021

Li, K., Fu, C., Cheng, H., & Tan, W. 2011. Anomalous Subdiffusion of Calcium Spark in Cardiac Myocytes. Cellular and Molecular Bioengineering: 1-9.

Zhang, X., Zhang, R., Raab, S., Zheng, W., Wang, J., Liu, N., Zhu, T., Xue, L., Song, Z., Mao, J., Li, K., Zhang, H., Zhang, Y., Han, C., Ding, Y., Wang, H., Hou, N., Liu, Y., Shang, S., Li, C., Sebokova, E., Cheng, H., & Huang, P. L. 2011. Rhesus Macaques Develop Metabolic Syndrome With Reversible Vascular Dysfunction Responsive to Pioglitazone / Clinical Perspective. Circulation, 124(1): 77-86.

Fang, H., Chen, M., Ding, Y., Shang, W., Xu, J., Zhang, X., Zhang, W., Li, K., Xiao, Y., Gao, F., Shang, S., Li, J.-C., Tian, X.-L., Wang, S.-Q., Zhou, J., Weisleder, N., Ma, J., Ouyang, K., Chen, J., Wang, X., Zheng, M., Wang, W., Zhang, X., & Cheng, H. 2011. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res, 21(9): 1295-1304.

Wang, G., Zhu, X., Xie, W., Han, P., Li, K., Sun, Z., Wang, Y., Chen, C., Song, R., Cao, C., Zhang, J., Wu, C., Liu, J., & Cheng, H. 2010. Rad As a Novel Regulator of Excitation–Contraction Coupling and β-Adrenergic Signaling in Heart. Circulation Research, 106(2): 317-327.

Yan, Y., Liu, J., Wei, C., Li, K., Xie, W., Wang, Y., & Cheng, H. 2008. Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes. Cardiovasc Res, 77(2): 432-441.

Wang, W., Fang, H. Q., Groom, L., Cheng, A. W., Zhang, W. R., Liu, J., Wang, X. H., Li, K., Han, P. D., Zheng, M., Yin, J. H., Wang, W. D., Mattson, M. P., Kao, J. P. Y., Lakatta, E. G., Sheu, S. S., Ouyang, K. F., Chen, J., Dirksen, R. T., & Cheng, H. P. 2008. Superoxide flashes in single mitochondria. Cell, 134(2): 279-290.

Luo, D., Yang, D., Lan, X., Li, K., Li, X., Chen, J., Zhang, Y., Xiao, R. P., Han, Q., & Cheng, H. 2008. Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Cell Calcium, 43(2): 165-174.

Deng, J., Wang, G., Huang, Q., Yan, Y., Li, K., Tan, W., Jin, C., Wang, Y., & Liu, J. 2008. Oxidative stress-induced leaky sarcoplasmic reticulum underlying acute heart failure in severe burn trauma. Free Radic Biol Med, 44(3): 375-385.