Dr. Ke Bai

1. HIV remains one of the world’s most serious health threats. As an enveloped virus, HIV transfers its genome into a cell by fusion of the viral membrane with the target cell membrane. In this project, we aim to develop a single-molecular complex approach to study the mechanisms of cell entry of the Human Immunodeficiency Virus (HIV), which includes study the kinetics of HIV envelope protein - T cell interaction, as well as observe the conformational changes in Env en route to membrane fusion. Here is a cartoon describing what people think that happens during this fusion process: https://www.youtube.com/watch?v=51z2dwdOLUE

2. The pre-TCR is crucial in the early T cell development, including TCR β selection and CD4 (-) CD8(-) double negative thymocyte survival and proliferation. Here we study the interaction of pre-TCR with pMHC and downstream the calcium signaling.

K. Bai, W. Wang (2014) Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro, Biomechanics and modeling in mechanobiology 13 (2), 303-311

W. Liu, X. Wang, K. Bai, M. Lin, G. Sukhorukov, W. Wang (2014) Microcapsules functionalized with neuraminidase can enter vascular endothelial cells in vitro. Journal of Royal Society-Interface 11 (101), 20141027

K. Bai, & W. Wang (2012) Spatio-temporal development of the endothelial glycocalyx layer and its mechanical property in vitro. Journal of Royal Society-Interface 9 (74):2290-8.

K. Bai, Y. Huang, X. -L. Jia, Y. -B. Fan, & W. Wang (2010) Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations. Journal of Biomechanics 43:1176-1181.

Y. Huang, X. Jia, K. Bai, X. Gong, & Y. Fan (2010) Effect of Fluid Shear Stress on Cardiomyogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells. Archives of Medical Research 41 (7):497-505

K. Bai, T. -H Zhang, Z. -Y Yang, F Song, X. -D Yang & K Wang (2007) Anisotropic, gradient and metal-like mechanical behaviour of teeth & their implication on tooth functions. Chinese Science Bulletin 52 (17): 2310-2315.

K. Bai, L. Yuan, Q. Xia, & X. -D. Yang (2007) Lanthanon transferrin as the drug delivery carrier in blood brain barrier. Chinese Patent No: ZL200710064153.2

K. -W. Xiao, K. Bai & F. Song (2007) Microstructure and nanomechanical properties of the wing membrane of a dragonfly. Materials Science and Engineering A 457 (1-2): 254-260.