Background
Current position: postdoctoral fellow at National Heart, Lung, and Blood Institute, NIH
Research
My project was to study 2D kinetics and force-regulation in TCR-pMHC interaction in T cell activation and thymocyte selection.
Publications
Hong, J., et al. (2015). "Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells." J Immunol 195(8): 3557-3564.
Chen, Y., et al. (2015). "Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell." J Vis Exp(102): e52975
Casas, J., et al. (2014). "Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor." Nat Commun 5: 5624
Pryshchep, S., et al. (2014). "Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells." J Immunol 193(1): 68-76.