Cellular and Molecular Biomechanics Laboratory

The laboratory of Dr. Cheng Zhu at Georgia Tech

Recent Publications

Type Date Title Link
9/23/2021 The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils. Full
8/6/2021 Distinct roles of ICOS and CD40L in human T-B cell adhesion and antibody production. Full
8/2/2021 Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus. Full
5/12/2021 PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Full
2/14/2020 From cellular to molecular mechanobiology. Full

Positions

Please email Dr. Cheng Zhu for more information

People

Principal Investigator

Dr. Cheng Zhu

cheng.zhu@bme.gatech.edu

Research Scientists

Dr. Kaitao Li

KaitaoLi@gatech.edu

Post-doctorates

Dr. Zhou Yuan

zyuan8@gatech.edu

Dr. Fangyuan Zhou

fzhou22@gatech.edu

Graduate Students

Makala Faniel

makalaf@gatech.edu

David Reyes Aguilar

daguilar31@gatech.edu

Valencia Watson

vwatson7@gatech.edu

Undergraduate Students

Laboratory Alumni

Jeffrey Butler

jbutler80@gatech.edu

Dr. Paul Cardenas-Lizana

pacl3@gatech.edu

Dr. Yunfeng Chen

chen.yunfeng@hotmail.com

Dr. Chenghao Ge

cge8@gatech.edu

Dr. Jingsung Hong

hjs0811@gmail.com

Dr. Prithi Jothikumar

pjothikuma3@gatech.edu

Dr. Hyun-Jung Lee

hjlee@gatech.edu

Dr. Jiexi Liao

jliao8@gatech.edu

Dr. Billy Rittase

william.rittase@gmail.com

Dr. Aaron Rosado

arosado@gatech.edu

Samuel Ruipérez Campillo

sruiperez3@gatech.edu

Dr. Muaz Rushdi

nmnr3@gatech.edu

Dr. Ning Wu

angelia_wu@126.com

Laboratory Staff

Research

Welcome!

Welcome to the Zhu lab. We study single molecular adhesion with force spectroscopy for various cells and disease models. We pioneered in the discovery of force-prolonged bond lifetime, or the "catch bond," using the biomembrane force probe paired with mutation studies and molecular dynamics simulations.

T Cell Development, Antigen Recognition, and Activation

T cells are an important subset of the immune system that plays a pivotal role in regulating various diseases. T cells functions are influenced both by biochemical and biophysical properties at local microenvironment that influences receptor-ligand interactions. Our goal is to understand how these interactions mediated by mechanical properties translate into intracellular signaling, thereby affecting cellular function and fate.

Platelet Mechanobiology

Platelets are key players in both hemostasis and thrombosis. Mechanical stimuli are important in the circulation system. We strive to understand platelet activation, mechanotransduction, and hyperreactivity by characterizing surface receptor-ligand binding kinetics and intracellular signaling using tools such as the biomembrane force probe, biosensors, and mutation studies.

Instruments

Biomembrane Force Probe

BFP

Measures single ligand-receptor interactions under force

Micropipette adhesion frequency assay

Measures adhesion frequency of single receptor-ligand interactions

Atomic force microscope

AFM

Home-made AFM that measures protein-protein binding kinetics

Horizontal atomic force microscope

HAFM

AFM on which the cantilever works horizontally (parallel to the earth); can measure receptor-ligand binding kinetics under force on live cells

Micropipette forge

Home-made micropipette factory: makes pipettes of various sizes

Publications

Title First Author Journal Date PMID DOI More Information
The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils. Fangyuan Zhou, Fang Zhang Journal of cell science 9/23/2021 11023892 10.1242/jcs.258046 More Info
Distinct roles of ICOS and CD40L in human T-B cell adhesion and antibody production. Zhicui Liu, Shuai Liu, Yan Zhang, Weihong Zeng, Shujun Wang, Ping Ji, Meng Pan, Cheng Zhu, Ying Wang Cellular immunology 8/6/2021 34418679 10.1016/j.cellimm.2021.104420 More Info
Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus. Cara T Motz, Victoria Kabat Advanced Healthcare Materials 8/2/2021 14012334 10.1002/adhm.202100102 More Info
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Kaitao Li Nature communications 5/12/2021 15358536 10.1038/s41467-021-22965-9 More Info
From cellular to molecular mechanobiology. Cheng Zhu APL bioengineering 2/14/2020 31965350 10.1063/1.5129937 More Info
Mechanotransduction in T Cell Development, Differentiation and Function. Muaz Rushdi, Kaitao Li Cells 2/5/2020 26051539 10.3390/cells9020364 More Info
Calibration for computer experiments with binary responses and application to cell adhesion study Chih-Li Sung, Ying Hung, William Rittase, Cheng Zhu, CF Wu Journal of the American Statistical Association 1/21/2020 None 10.1080/01621459.2019.1699419 More Info
Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex. Zhenhai Li, Hyunjung Lee, Suzanne G. Eskin, Shoichiro Ono, Cheng Zhu, Larry V. McIntire Biomechanics and modeling in mechanobiology 1/21/2020 12525176 10.1007/s10237-019-01284-5 More Info
Single-molecule investigations of T-cell activation. Kaitao Li, William Rittase Current opinion in biomedical engineering 11/1/2019 27192323 10.1016/j.cobme.2019.10.005 More Info
Dynamic bonds and their roles in mechanosensing. Cheng Zhu Current opinion in chemical biology 9/27/2019 27065098 10.1016/j.cbpa.2019.08.005 More Info

Contact Zhu Lab

If you would like to contact the laboratory of Dr. Cheng Zhu, please get in touch with Larissa (E-mail)

For information about web design or web application design used in this website please contact Aaron (E-mail)

The website is administrated by Jiexi Liao (E-mail)