A nonsynonymous functional variant in integrin-alphaM (encoded by ITGAM) is associated with systemic lupus erythematosus

Author: Nath S. K.

Date: 2/1/2008

Journal:Nature Genet.


DOI: 10.1038/ng.71


We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.